Inflammation in acute coronary syndrome: prognostic significance

Abstract Funding Acknowledgements Type of funding sources: None. Background In patients with acute coronary syndrome (ACS) the phase reactant, C-reactive protein (CRP), might be significantly elevated. Several reports suggest that CRP may play a direct pathophysiological role on development and progression atherosclerosis, values correlate infarct size when measured by magnetic resonance imaging. Purpose The aim present study was to evaluate prognostic value in presenting an ACS. Methods Retrospective analysis 635 consecutively admitted due ACS single intensive care unit. levels were at admission. Clinical variables therapeutic strategies examined. primary endpoint analysed during follow-up all-cause mortality. Possible predictors for mortality assessed Cox regression models. When statistically significant found univariate analysis, multivariate used determine whether independent predictor outcome. Results studied sample, 75% male. Median age 69 [interquartile range (IQR) 57–78]. ST-elevation myocardial infarction (STEMI) occurred 39.6%, non-ST segment elevation 44.9% unstable angina 15.5% patients. left ventricular ejection fraction (LVEF) 48% (IQR 40–55%) median level admission 0.7 mg/dL 0.5–1.9 mg/dL). Regarding important comorbidities past medical history, 75.9% had hypertension (HTN), 34.0% diabetes, 20.3% chronic kidney disease (CKD), 68.6% dyslipidaemia 17.3% heart failure (HF). 34 months 22–72). associated (HR 1.06 per 1 increase, 95% CI 1.04–1.08, p<0.001), as gender, age, LVEF, STEMI previous history HTN, CKD or HF. remained 1.02, 1.00–1.05, p=0.033), did LVEF Conclusions our study, risk factor following This finding indicates inflammation event has impact long-term prognosis. More evidence is needed if treating (and when, course disease) could result better outcomes.